Title | Emerging strategies for spatiotemporal control of stem cell fate and morphogenesis. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Kinney, MA, McDevitt, TC |
Journal | Trends in Biotechnology |
Date Published | February 2013 |
ISSN | 1879-3096 |
Keywords | Animals, Cell Culture Techniques, Cell Differentiation, Extracellular Matrix, Humans, Signal Transduction, Stem Cells |
Abstract | Stem cell differentiation is regulated by the complex interplay of multiple parameters, including adhesive intercellular interactions, cytoskeletal and extracellular matrix remodeling, and gradients of agonists and antagonists that individually and collectively vary as a function of spatial locale and temporal stages of development. Current approaches to direct stem cell differentiation focus on systematically understanding the relative influences of microenvironmental perturbations and simultaneously engineering platforms aimed at recapitulating physicochemical aspects of tissue morphogenesis. This review focuses on novel approaches to control the spatiotemporal dynamics of stem cell signaling and morphogenic remodeling to direct the differentiation of stem cells and develop functional tissues for in vitro screening and regenerative medicine technologies. |
DOI | 10.1016/j.tibtech.2012.11.001 |
Alternate Journal | Trends Biotechnol. |
PubMed ID | 23219200 |
PubMed Central ID | PMC3557560 |
Grant List | R01 GM088291 / GM / NIGMS NIH HHS / United States R01 EB010061 / EB / NIBIB NIH HHS / United States GM088291 / GM / NIGMS NIH HHS / United States EB010061 / EB / NIBIB NIH HHS / United States AR062006 / AR / NIAMS NIH HHS / United States R21 EB007316 / EB / NIBIB NIH HHS / United States |