TitleStem cell paracrine actions and tissue regeneration.
Publication TypeJournal Article
Year of Publication2010
AuthorsBaraniak, PR, McDevitt, TC
JournalRegenerative Medicine
Date PublishedJanuary 2010
KeywordsHumans, Paracrine Communication, Regeneration, Regenerative Medicine, Stem Cells, Wound Healing

Stem cells have emerged as a key element of regenerative medicine therapies due to their inherent ability to differentiate into a variety of cell phenotypes, thereby providing numerous potential cell therapies to treat an array of degenerative diseases and traumatic injuries. A recent paradigm shift has emerged suggesting that the beneficial effects of stem cells may not be restricted to cell restoration alone, but also due to their transient paracrine actions. Stem cells can secrete potent combinations of trophic factors that modulate the molecular composition of the environment to evoke responses from resident cells. Based on this new insight, current research directions include efforts to elucidate, augment and harness stem cell paracrine mechanisms for tissue regeneration. This article discusses the existing studies on stem/progenitor cell trophic factor production, implications for tissue regeneration and cancer therapies, and development of novel strategies to use stem cell paracrine delivery for regenerative medicine.

Alternate JournalRegen Med
PubMed ID20017699
PubMed Central IDPMC2833273
Grant ListEB007316 / EB / NIBIB NIH HHS / United States
R21 EB007316 / EB / NIBIB NIH HHS / United States
R21 EB007316-02 / EB / NIBIB NIH HHS / United States
UL1 RR025008 / RR / NCRR NIH HHS / United States