TitleEmerging strategies for spatiotemporal control of stem cell fate and morphogenesis.
Publication TypeJournal Article
Year of Publication2013
AuthorsKinney, MA, McDevitt, TC
JournalTrends in Biotechnology
Date PublishedFebruary 2013
KeywordsAnimals, Cell Culture Techniques, Cell Differentiation, Extracellular Matrix, Humans, Signal Transduction, Stem Cells

Stem cell differentiation is regulated by the complex interplay of multiple parameters, including adhesive intercellular interactions, cytoskeletal and extracellular matrix remodeling, and gradients of agonists and antagonists that individually and collectively vary as a function of spatial locale and temporal stages of development. Current approaches to direct stem cell differentiation focus on systematically understanding the relative influences of microenvironmental perturbations and simultaneously engineering platforms aimed at recapitulating physicochemical aspects of tissue morphogenesis. This review focuses on novel approaches to control the spatiotemporal dynamics of stem cell signaling and morphogenic remodeling to direct the differentiation of stem cells and develop functional tissues for in vitro screening and regenerative medicine technologies.

Alternate JournalTrends Biotechnol.
PubMed ID23219200
PubMed Central IDPMC3557560
Grant ListR01 GM088291 / GM / NIGMS NIH HHS / United States
R01 EB010061 / EB / NIBIB NIH HHS / United States
GM088291 / GM / NIGMS NIH HHS / United States
EB010061 / EB / NIBIB NIH HHS / United States
AR062006 / AR / NIAMS NIH HHS / United States
R21 EB007316 / EB / NIBIB NIH HHS / United States