Josh graduated with a Bachelor of Science and Masters of Science in Biomedical Engineering from Case Western Reserve University. His undergraduate and Masters research focused primarily on the influence of the mechanical environment of mesenchymal stem cells on cell morphology and differentiation. He is currently pursuing a Ph.D. in biomedical engineering at Georgia Tech & Emory University.
The immunomodulatory properties of mesenchymal stem cells (MSCs) have gained interest for their potential as cellular therapies for inflammatory and immune diseases. MSCs secrete numerous paracrine factors that regulate multiple signaling pathways and immune cell types that contribute to the pathogenesis of inflammatory and immune diseases. Josh is currently investigating environmental regulation of MSC immunomodulatory factor secretion and engineering the microenvironment to enhance the inherent immunomodulatory potential of MSCs.