NSF Graduate Research Fellow
Graduate Student

Biography

Oriane graduated from Duke University in 2014 with a Bachelors degree in Biomedical Engineering and a minor in Mathematics. As a Pratt Undergraduate Research Fellow in the laboratory of Professor William M. Reichert, she worked on self-healing biomaterials, investigating the mechanical properties and biocompatibility of acrylic bone cement embedded with microencapsulated 2-octyl cyanoacrylate. Oriane became increasingly interested in stem cell engineering throughout her undergraduate research experiences and joined the McDevitt laboratory in January 2015 after the move to the Gladstone Institutes. In August 2015, she started the Bioengineering PhD Program at the University of California, Berkeley and the University of California, San Francisco.

Awards

Theo C. Pilkington Memorial Award (Duke University, 2014) Howard G. Clark Award (Duke University, 2014)
Recent Publications:
  

Design Principles for Engineering of Tissues from Human Pluripotent Stem Cells.

Related Articles

Design Principles for Engineering of Tissues from Human Pluripotent Stem Cells.

Curr Stem Cell Rep. 2016 Mar;2(1):43-51

Authors: Matthys OB, Hookway TA, McDevitt TC

Abstract
Recent advances in human pluripotent stem cell (hPSC) technologies have enabled the engineering of human tissue constructs for developmental studies, disease modeling, and drug screening platforms. In vitro tissue formation can be generally described at three levels of cellular organization. Multicellular hPSC constructs are initially formed either with polymeric scaffold materials or simply via self-assembly, adhesive mechanisms. Heterotypic interactions within hPSC tissue constructs can be achieved by physically mixing independently differentiated cell populations or coaxed to simultaneously co-emerge from a common population of undifferentiated cells. Higher order tissue architecture can be engineered by imposing external spatial constraints, such as molds and scaffolds, or depend upon cell-driven organization that exploits endogenous innate developmental mechanisms. The multicellular, heterogeneous, and highly organized structure of hPSC constructs ultimately dictates the resulting form and function of in vitro engineered human tissue models.

PMID: 27330934 [PubMed - as supplied by publisher]