Senior Investigator, Gladstone Institute of Cardiovascular Disease
Professor, Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco
Investigator, Roddenberry Center for Stem Cell Biology & Regenerative Medicine at Gladstone

Biography

Todd McDevitt’s research focuses on engineering technologies that direct the differentiation and morphogenesis of stem cells into functional tissue constructs. The lab is working to create human tissue models that can be used to study development and new approaches to treat multiple diseases that afflict the cardiovascular, neurological, immunological, and musculoskeletal systems.

He has received several honors and awards for research, mentoring and teaching which include: New Investigator Award from the American Heart Association and the Society for Biomaterials Young Investigator Award and was inducted in the American Institute of Medical and Biological Engineering College of Fellows and most recently, was awarded the California Institute of Regenerative Medicine (CIRM) Research Leadership Award, which enabled his move to the Gladstone Institutes in San Francisco in 2015.

Areas of Investigation
We are studying stem cell differentiation and morphogenesis to engineer three-dimensional, multicellular systems that can be used to study principles of stem cell and developmental biology. We are designing many new technologies to better control and assess stem cell phenotypes, with a particular focus on scalable methods and non-destructive analyses that are directly and immediately relevant to biomanufacturing needs. We are creating novel biotherapeutic approaches based on factors derived from stem cells to facilitate regenerative molecular therapies and engineer new platforms that can model and treat a variety of biomedical problems, including cardiovascular disease, neurological and immunological disorders, and traumatic musculoskeletal injuries.  

Current Lab Focus

•    What are the roles of physical and biochemical factors in the extracellular environment that regulate decisions in stem-cell fate, particularly in 3D environments?

•    What are the critical mechanisms that regulate differentiation and morphogenesis of embryonic tissues during development, and how can we engineer these processes?

•    How can we create functional 3D models of human tissues from pluripotent stem cells, such as heart, spinal cord, bone, and cartilage?

•    How can we engineer technologies to deliver factors secreted from stem cells to regenerate tissue, ameliorate disease, and modulate the inflammatory and immune system?

•    What tools and technologies do we need to develop that we can directly integrate into bioprocessing systems to manufacture stem cells at high yields?

Education & Training
Todd graduated with cum laude with a Bachelor of Science in Engineering (BSE) from Duke University in 1997 after double majoring in Biomedical Engineering and Electrical Engineering. Todd received his PhD in Bioengineering from the University of Washington in 2001. He completed his dissertation research in the laboratory of Patrick Stayton working on protein engineering and micropatterning techniques to spatially control cell assembly for cardiac and skeletal muscle tissue engineering. In 2001, Todd joined Chuck Murry's lab in the Department of Pathology as a post-doctoral fellow. His post-doctoral research focused on signaling pathways mediating proliferation of cardiomyocytes derived from stem cells for the purpose of myocardial repair.

Georgia Tech
Todd moved to the Gladstone Institutes in 2015 after a successful ten years at Georgia Tech. During his tenure, Todd was held the following positions: Carol Ann and David D. Flanagan Professor in the Wallace H. Coulter Department of Biomedical Engineering, a Petit Faculty Fellow of the Parker H. Petit Institute for Bioengineering and Bioscience at Georgia Tech, and the founding Director of the Stem Cell Engineering Center at Georgia Tech. McDevitt was the PI of the $3.6 million NSF Integrated Graduate Education and Research Training (IGERT) program on Stem Cell Biomanufacturing which was highlighted in Nature as an "out-of-the-box" novel graduate training program. In addition, Todd was appointed to a six-member panel of North American experts by the National Science Foundation to a conduct an international assessment of stem cell engineering research and development efforts that is intended to inform strategic investments by the U.S. in this emerging area of biotechnology.

 

Education

Bachelor of Science in Engineering, Biomedical Engineering & Electrical Engineering
Duke University
1997

Doctorate of Philosophy, Bioengineering
University of Washington
2001

Awards

SELECT AWARDS

  • CIRM Research Leadership Award - 2015
  • Elected as Fellow of the American Institute for Medical and Biological Engineering (AIMBE) - 2014
  • 1 of 20 Georgia Top Medical Researchers by Atlanta Business Chronicle - 2014
  • "40 under 40" Georgia Trend Magazine - 2013
  • Best Advisor from the BioEngineering Graduate Program - 2013  
  • Above and Beyond (Eagle) Award, Georgia Tech Biomedical Engineering Society - 2011
  • National Academy of Engineering, China-America Frontiers of Engineering
  • Invited Attendee UK-US Collaboration Development Award
  • Most Influential Georgians (Notables), Georgia Trend Magazine - 2010  
  • Young Investigator Award Winner, Society for Biomaterials 
  • Junior Faculty Outstanding Undergraduate Research Mentor Award 
  • Most Influential Georgians (Notables), Georgia Trend Magazine - 2009
  • IBB Interdisciplinary Research & Education Above & Beyond Award - 2009
  • Petit Faculty Fellow, Institute for Bioengineering and Bioscience - 2009
  • 2008 UK-US Stem Cell Collaboration Development Award
  • Merck "Best Overall" poster at 1st SBE Stem Cell Engineering Conference  

Click here to view all McDevitt Lab Awards & Fellowships

Recent Publications:
    

Hettiaratchi MH, Rouse T, Chou C, Krishnan L, Stevens HY, Li M-TA, et al. Enhanced in vivo retention of low dose BMP-2 via heparin microparticle delivery does not accelerate bone healing in a critically sized femoral defect. Acta Biomaterialia. 2017;.
Griffin FE, Schiavi J, McDevitt TC, McGarry JP, McNamara LM. The role of adhesion junctions in the biomechanical behaviour and osteogenic differentiation of 3D mesenchymal stem cell spheroids. Journal of Biomechanics. 2017;.
Hettiaratchi MH, Chou C, Servies N, Smeekens JM, Cheng A, Esancy C, et al. Competitive protein binding influences heparin-based modulation of spatial growth factor delivery for bone regeneration. Tissue Engineering Part A. 2017;.
Butts JC, McCreedy DA, Martinez-Vargas JAlexis, Mendoza-Camacho FN, Hookway TA, Gifford CA, et al. Differentiation of V2a interneurons from human pluripotent stem cells. Proceedings of the National Academy of Sciences. 2017;.
Allen AB, Zimmermann JA, Burnsted O, Yakubovich DCohn, Stevens HY, Gazit Z, et al. Environmental manipulation to promote stem cell survival in vivo: Use of aggregation, oxygen carrier, and BMP-2 co-delivery strategies. Journal of Materials Chemistry B. 2016;.