Lab Overview

The McDevitt lab is focused on the engineering of innovative technologies to translate the morphogenic potential of stem cells as models of development and disease, as well to develop cellular and molecular therapies aimed to treat degenerative diseases and traumatic injuries. Learn more about the research.

Since stem cells are promising for a number of applications, the emphasis of the McDevitt Lab is on the development of technology platforms to advance therapies that span multiple diseases.

Our technologies are applicable to a wide variety of diseases, including cardiovascular, orthopedic and neurological disorders. Specific diseases that we can apply our research to include treatments for diabetes, chronic wounds, aging, arthritis and other autoimmune disorders. The McDevitt lab's work also has other applications, including wound healing, irritable bowel syndrome, epilepsy and bone regeneration to name just a few. Click here for a complete list of research and disease applications.


  • Overview of Stem Cell Engineering
  • Todd was 1 of 6 panelists that toured Europe and Asia to do an international assessment of the Stem Cell Engineering field.


Experiments with adding a heparin mixture with clinically relevant levels of bone morphogenetic protein leads to significant reductions of ossification in preclinical and computer modeling
Hear Todd describe his recent work published in Cell Systems used machine learning to predict and control pluripotent stem cell self-organization, which could be used for developing 3D organ models and tissues.
Gladstone researchers discovered a method to control the patterns stem cells form in a dish.
The McDevitt Lab at Gladstone used a machine-learning approach to discover new ways of controlling the spatial organization of induced pluripotent stem cells
Novel Approach Could Streamline the Creation of Mini-organs.
Building on Shinya Yamanaka’s human induced pluripotent stem cells, Gladstone researchers are developing creative strategies to use stem cells toward understanding and treating diseases.