Since stem cells are promising for a number of applications, the emphasis of the McDevitt Lab is on the development of technology platforms to advance therapies that span multiple diseases.

Autoimmune

Stem cells are naturally anti-inflammatory, but often do not survive or function long enough to exert full therapeutic benefit. Inflammatory and immune diseases, such as type I diabetes, arthritis, multiple sclerosis, lupus, Crohn’s disease, inflammatory bowel diseases

Bone

Severe bone loss resulting from trauma, disease, or infection affects thousands of people each year. Currently, the gold standard of care for bone defects is autologous or allogenic bone grafting, in which an explanted piece of bone is placed to fill the bone defect. However, bone grafting suffers from a

Cardiac

The high mortality and morbidity rates related to cardiovascular disease worldwide has prompted tissue engineering and regenerative medicine approaches to study cardiovascular development, disease, and tissue homeostasis. Following cardiac infarction, few mechanisms exist to regenerate the damaged

Cartilage and Osteoarthritis

Articular cartilage degeneration such as osteoarthritis is one of the most common causes of chronic pain, stiffness, and loss of joint movement in middle-aged and older population. The repair of the damaged cartilage using autologous chondrocytes is often compromised by their limited capacity for

Epilepsy

Epilepsy is a neurological disorder that occurs in 3% of the population and affects people of all demographics.  Epilepsy is characterized by reoccurring seizures – an excessive, synchronous electrical discharge of a population of neurons in the brain.  High variability in phenotypes and

Neuro

Neural tube defects affect over 300,000 births a year globally. Furthermore, in 2012, it was estimated approximately 270,000 people live with a spinal cord injury in the United States with the majority of injuries occurring between the ages of 16 and 30. Better understanding of neural tube development and

Wound Healing

Skin regeneration following wounding is an essential process in maintaining tissue homeostasis and preventing infection. However, the natural process of healing is disrupted in many pathological conditions, resulting in chronic wounds that remain open for months, or even years. Chronic wounds are a common